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Bassem Al-Sady - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: to be negotiated Location: On Campus
Genes in our genome can be kept in active or inactive states in different cell types. Genes coding for opposing cell types are heritably kept inactive. This is possible because a gene repressive structure called heterochromatin can “grow” over regions containing these genes in some, but not other cell types...
James Bayrer - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 3-5 hrs Location: On Campus
The intestinal lining undergoes continual renewal, with a near total turnover of epithelial cells occurring every week. Powering this metabolically intense task are the intestinal stem cells that divide and restore the intestine. Understanding how intestinal stem cells can both contribute to normal homeostasis and the repair of damaged tissue...
Jeff Belkora - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: Off Campus
STUDENT TESTIMONIALS “This apprenticeship has been the highlight of my time at Berkeley. It has given me a chance to help patients in difficult medical situations, and as a pre-health undergraduate, this is important to me.” “It is a great opportunity to get clinical experience and work with like...
Biological & Health Sciences Social Sciences Engineering, Design & Technologies Education, Cognition & PsychologyAndy Chang - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: Off Campus
The carotid body is a mammalian chemoreceptor that senses changes in blood oxygen to regulate breathing. However, carotid body becomes hyperactive in chronic diseases like hypertension, sleep apnea, chronic heart failure, and metabolic syndrome, and ablation of carotid body activity improves symptoms like hypertension, cardiac arrhythmia, and insulin resistance. We...
Biological & Health SciencesJohn Chorba - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
PCSK9 chaperones the low-density lipoprotein receptor (LDLR) to the lysosome for degradation, thereby raising circulating LDL (i.e. “bad” cholesterol) and accelerating atherosclerosis and heart disease. Despite its validation as a drug target, PCSK9 has proven difficult to drug with small molecules, at least in part because of its single...
Biological & Health SciencesJohn Chorba - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: On Campus
The LDL receptor clears atherogenic LDL particles from the bloodstream and plays a major role in cholesterol and membrane homeostasis. Through a genome-wide CRISPR interference screen, we identified novel regulators of the LDL receptor as potential therapeutic targets for cholesterol lowering. We have shown that CSDE1 is an RNA...
Biological & Health SciencesJohn Chorba - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated
A fundamental challenge in drug discovery is that any given therapeutic target requires its own customized strategy. The discovery of a recent compound that binds the human ribosome and inhibits translation in a sequence specific manner offers the potential to “drug” protein targets without the need for a traditional active...
Biological & Health SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: Off Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence and 4D ultrasound imaging...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: On Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging technology, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence imaging and 4D...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesJan Christoph - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: Off Campus
It is an exciting time in cardiovascular research: the combination of 3D imaging technology, deep learning, numerical modeling and high-performance computing opens doors to novel diagnostic capabilities. Our group develops computational and experimental methods for the imaging of the heart. We produce imaging data using fluorescence imaging, catheter-based...
Engineering, Design & Technologies Biological & Health Sciences Mathematical and Physical SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Many painful pathologies of the spine involve the first sacral (S1) vertebra. For example, damage to the endplates of S1 (in particular, the region near the lumbar intervertebral disc) can cause painful lesions in the vertebral bone marrow—such lesions are relatively common in patients with chronic low back pain...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Advances in magnetic resonance imaging (MRI) technology enable novel, quantitative, and non-invasive estimation of the biochemical composition of musculoskeletal tissues. The new ability to non-invasively assay tissue composition using MRI has major implications for understanding spinal pathologies related to low back pain, such as intervertebral disc degeneration. Recent...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The Orthopaedic Biomechanics and Biotransport Laboratory at UCSF conducts research related to structure-function relationships in musculoskeletal tissues, with a particular focus on the mechanisms of nutrient transport in bone and cartilage and harnessing nutrient transport for tissue repair and regeneration. The lab combines engineering and biology approaches for (1...
Biological & Health SciencesAaron Fields - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The Orthopaedic Biomechanics and Biotransport Laboratory at UCSF conducts research related to structure-function relationships in musculoskeletal tissues, with a particular focus on the mechanisms of nutrient transport in bone and cartilage and harnessing nutrient transport for tissue repair and regeneration. The lab combines engineering and biology approaches for (1...
Biological & Health SciencesLea Grinberg - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
Are you from Computer Science and want to know how to program in an agile project? Ok, this position is for you! We must have all our sample inventory organized… but it is time to be modern! We need a web application to do that! Do we know exactly how...
Biological & Health SciencesLea Grinberg - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: Off Campus
Background: Sleep disturbance is common among patients with neurodegenerative diseases. For instance, patients with Alzheimer’s disease (AD) experience excessive daytime sleepiness and sundowning. Progressive supranuclear palsy (PSP) features hyperarousal and decreased homeostatic sleep drive. Sleep disturbance generally precedes disease-defining symptoms, often by decades, suggesting that dysregulation of sleep is...
Biological & Health SciencesLea Grinberg - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: Off Campus
The importance of histology to neuropathological research cannot be overstated. As a neurology lab, the histological characterization of proteopathies (including tauopathies, Aβ-amyloidosis, synucleiopathies, etc.) is core to our operations. From determining severity/progression of the pathology to identifying areas of selective vulnerability, immunohistochemistry and microscopy are critical tools for...
Biological & Health SciencesLea Grinberg - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 9-11 hrs Location: Off Campus
Despite intensive research on AD, effective disease-modifying treatments remain elusive, and novel tools for non-invasively assessing early brains lesions are needed. Our lab confirmed that the brain structures that consistently exhibit the earliest neuropathologic changes in AD, including neuronal loss, are not classically AD-associated cortical regions, but...
Biological & Health SciencesRoland Henry - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The ability to quantitatively measure changes to the central nervous system is approaching a crucial milestone for neuro-imaging - the ability to measure change on an individual patient level. The Multiple Sclerosis Center at UCSF, in concert with our partners, has prioritized the development of a panoply of neuro-imaging...
Biological & Health Sciences Education, Cognition & Psychology Engineering, Design & TechnologiesRoland Henry - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
UCSF’s Department of Radiology and Biomedical Imaging and Department of Neurology are excited to offer a combined educational and research opportunity for motivated undergraduate students in the medical imaging research team. 3D segmentation of structures in the brain and spinal cord is a problem that deep learning is uniquely equipped...
Biological & Health Sciences Education, Cognition & Psychology Engineering, Design & TechnologiesRoland Henry - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
UCSF’s Department of Neurology has some of the largest clinical neuroimaging datasets in the world. As the director of imaging for the multiple sclerosis group, Dr. Roland Henry’s laboratory is in charge of making sense of this data and applying next generation analytical techniques to translate this raw data into...
Biological & Health Sciences Education, Cognition & Psychology Engineering, Design & TechnologiesJulian Hong - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
The Hong lab is part of the UCSF Department of Radiation Oncology and Bakar Computational Health Sciences Institute. We focus on combining clinical domain knowledge with data science to generate insights from real world data, develop actionable computational tools, and evaluate the benefit of these advances for personalized cancer care...
Digital Humanities and Data Science Biological & Health SciencesGuo Huang - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
As shown in our recent publication (Hirose*, Payumo*, et al Science 2019), we aim to understand the divergent regenerative potential in ontogeny and phylogeny. For example, heart regeneration is remarkably robust in adult zebrafish and newborn mice while very limited in adult mammals. We use the heart as a model...
Biological & Health SciencesGuo Huang - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
We aim to study whether there are extreme physiological phenomena (1) in individuals with healthy low heart rates (less than 45 beats/min) and (2) among identical twins that can not be explained by any known biological mechanism. We will exploit classical and non-classical model systems to explore these...
Biological & Health SciencesGuo Huang - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Current studies of mouse heart regeneration are largely limited to postmortem analysis of heart tissue to explore cellular activity and molecular mechanisms. We aim to combine a novel imaging window system designed and surgically implanted on the mouse chest by the Huang Lab at UCSF with the free-space angular...
Biological & Health SciencesLaurence Huang - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
Chronic obstructive pulmonary disease (COPD) is the most frequent HIV-associated chronic lung disease and its clinical significance is increasing as the HIV+ population ages worldwide. Although both HIV-related and COPD-specific causes are postulated, our understanding of the mechanisms underlying HIV+ COPD is limited. An improved understanding is...
Biological & Health SciencesGalateia Kazakia - Professor, UC San Francisco, Electrical Engineering and Computer Science
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Our research group focuses on advanced imaging techniques for the study of musculoskeletal structure and function (for details please see: http://www.radiology.ucsf.edu/research/kazakia). For this project, we plan to use two recently developed imaging tools to investigate the structure and composition of bone. State-of-the-art micro computed...
Biological & Health Sciences Engineering, Design & TechnologiesGalateia Kazakia - Professor, UC San Francisco, Electrical Engineering and Computer Science
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Our research group focuses on advanced imaging techniques for the study of musculoskeletal structure and function (for details please see: http://www.radiology.ucsf.edu/research/kazakia). For this project, we will be performing advanced image processing and analysis on high resolution computed tomography (CT) images of the skeleton. These images are being...
Biological & Health Sciences Engineering, Design & TechnologiesQihui Lyu - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 12 or more hours Location: Off Campus
This project aims to improve metal artifacts in Computed Tomography (CT) images. In the presence of highly attenuating objects such as dental fillings, spinal screws/rods, hip prostheses, and gold fiducial markers, CT images are often corrupted by streak artifacts, making these images non-diagnostic and impacting the accuracy of...
Dengke Ma - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 12 or more hours Location: On Campus
Genome evolution has enabled organisms to live in and adapt to nearly every ecological niche on Earth. Humans live in an oxygen-rich ecosystem and human tissues are susceptible to deprivation of oxygen (hypoxia) under pathological conditions, including ischemic stroke and heart attack. Many organisms, from anaerobic bacteria to hibernating...
Biological & Health SciencesDengke Ma - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The nematode C. elegans can be frozen alive, suspend life and revive later virtually any long after freezing, unlike many other multicellular organisms, including flies, fish, mice and humans. How C. elegans achieves this feat remains a fascinating unsolved mystery. This project will use our newly established reporters and assays...
Biological & Health SciencesWilliam Martinez - Professor , UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The present study is a randomized control trial to evaluate the efficacy and effectiveness of a school-based group prevention program (Fuerte) in San Francisco Unified School District (SFUSD) Public Schools. Fuerte targets newcomer Latinx immigrant youth (five years or less post arrival in the U.S.) who are at risk...
Education, Cognition & Psychology Social SciencesJulian Motzkin - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: to be negotiated Location: Off Campus
When pain becomes chronic, there can be changes in brain areas involved with processing pain signals. Our research combines fMRI of pain circuits with repetitive transcranial magnetic stimulation (rTMS), a type of non-invasive brain stimulation, to determine how rTMS may alleviate difficult-to-treat pain...
Biological & Health SciencesYuko Oda - Research Staff, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The goal of our research is to identify a mechanism how somatic stem cells determine their cell fate through stage or cell specific transcriptional and epigenetic program. We hypothesized that the vitamin D receptor and its regulator of Mediator is critical for temporal or spatial specific transcription to control epithelial...
Biological & Health SciencesPedro Pinheiro-Chagas, UC San Francisco
Status: Current Term Now Closed Weekly Hours: to be negotiated Location: Off Campus
The UCSF Memory and Aging Center (MAC) Co-pilot project is an innovative research initiative aimed at revolutionizing the diagnosis of neurodegenerative diseases (NDD), such as Alzheimer's disease and Frontotemporal dementia, through the integration of advanced Large Language Models (LLMs). This project is particularly significant due to the high prevalence...
Biological & Health Sciences Digital Humanities and Data SciencePedro Pinheiro-Chagas, UC San Francisco
Status: Current Term Now Closed Weekly Hours: to be negotiated
Alzheimer’s disease and related dementias are neurodegenerative diseases with numbers rapidly increasing and currently no cure. To accurately identify the earliest signs of clinical dementia, there is a critical need for sensitive, low-cost, and high-access cognitive markers in the preclinical phase. Novel cognitive markers can complement biomarker information...
Biological & Health Sciences Digital Humanities and Data SciencePedro Pinheiro-Chagas, UC San Francisco
Status: Current Term Now Closed Weekly Hours: to be negotiated
Semantic dementia (SD) presents as a unique neurodegenerative disorder with focal atrophy of the anterior temporal lobes (ATLs). It is comprised of a primarily left-lateralized language syndrome and a right-lateralized behavioral disorder. One current challenge in this disease is in accurately identifying the distant brain regions that are...
Biological & Health Sciences Digital Humanities and Data ScienceLicia Selleri - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: to be negotiated Location: Off Campus
Craniofacial malformations are among the most common birth defects. Cellular and molecular programs underlying neural and craniofacial development are mediated by various signaling pathways, including those directed by calcium. Conserved involvement of calcium signaling has been implicated in craniofacial morphogenesis across species, from avian to mammal, but the mechanisms by...
Biological & Health SciencesYoungho Seo - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: Off Campus
Keywords: cancer, radiopharmaceutical therapy, targeted alpha therapy, alpha particles, image processing, dosimetry, machine learning, digital autoradiography Radiopharmaceutical therapy with alpha-particle emitters (⍺RPT) is an emerging cancer treatment method that has demonstrated high efficacy in clinical trials for several types of cancer. Improvement of these drugs requires thorough pre-clinical...
Biological & Health Sciences Engineering, Design & TechnologiesYoungho Seo - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
Molecular imaging is a powerful method of interrogating biochemical properties of imaging subjects. Particularly in research, we use small animal positron emission tomography (PET) and single photon emission computed tomography (SPECT), which are combined with x-ray computed tomography (CT). More commonly, these imaging modalities are known as microPET/CT...
Biological & Health Sciences Engineering, Design & TechnologiesYoungho Seo - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 6-8 hrs Location: Off Campus
Radiotherapy with alpha-emitting nuclides is an extremely promising technique in cancer therapy. The very short range of alpha particles compared to beta particles allows to deliver a much higher therapeutical dose to the lesion, sparing healthy tissue. A fundamental problem with this technique is the inability of current radiation...
Biological & Health Sciences Engineering, Design & TechnologiesYoungho Seo - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: Off Campus
Keywords: deep learning, artificial intelligence, prediction, Alzheimer's disease, positron emission tomography, PET, image processing, FDG, glucose metabolism, amyloid Alzheimer's disease (AD) is the most common type of dementia, and a debilitating condition that affects a large number of aging populations. When symptoms occur, there are a very limited set of...
Biological & Health Sciences Engineering, Design & TechnologiesJae Ho Sohn - Professor, UC San Francisco
Status: Current Term Now Closed Weekly Hours: 6-8 hrs Location: Off Campus
Radiologists are doctors who specialize in extracting clinically useful information from medical images (such as CT, chest X-ray, and MRIs) and communicating these findings with other doctors. We leverage abstract clinical reasoning and visual pattern recognition skills to extract hidden information in the images that may be important for...
Biological & Health Sciences Digital Humanities and Data ScienceVasanth Vedantham - Professor, UC San Francisco
Status: Full- no new appr needed Weekly Hours: 9-11 hrs Location: Off Campus
The heart’s spontaneous rhythmicity has fascinated natural scientists from antiquity to the present. Particularly in the form of the palpable pulse, heart rhythm has always been among the most accessible physiological parameters to physicians, athletes and lay people, and yet the evolution, ontogenesis, and regulation of the heartbeat have remained...